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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: In vivo induction of membrane damage by β-amyloid peptide oligomers

Fig. 4

Effects of amph-1, unc-11 and clp-4 mutations on Aβ-induced intestinal endosomes. a Strains containing the vha-6::mCherry reporter and deletion mutations in amph-1, unc-11, or clp-4 were fed E. coli expressing wild type Aβ1–42. Note that the amph-1 and unc-11 mutations increase, while the clp-4 mutation decreases, the accumulation of intestinal endosomes. b Treatment with the calpain inhibitor PD150606 replicates the ability of the clp-4 mutation to block Aβ-induced increases in intestinal endosomes. c RNAi treatments indicate the clp-4 deletion mutation is epistatic to the effects of amph-1 and unc-11 knockdown. *p < 0.05, **p < 0.01 and ***p < 0.001 when compared with the vehicle control

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