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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: In vivo induction of membrane damage by β-amyloid peptide oligomers

Fig. 2

Induction of intestinal endosomes in C. elegans fed E. coli that express human Aβ peptide. a Live images of C. elegans reporter strain KWN117 (vha-6::mCherry) fed E. coli expressing either vector control, CRY5B toxin, wild type Aβ1–42, or Aβ1–42 Gly37Leu. Note that both CRY5B and wild type Aβ1–42 induce intestinal endosomes (arrows) containing the vha-6::mCherry reporter usually associated with the lumenal membrane of the intestine. This induction does not occur in worms fed E. coli expressing the non-pore-forming Aβ1–42 Gly37Leu variant. b Quantification of endosome induction. c Super resolution image of intestinal endosomes induced in strain KWN117 by wild type Aβ1–42. The treated worm was subsequently fixed, permeabilized, and probed using anti-Aβ antibody 6E10. Note that the Aβ staining co-localizes with the membrane-associated vha-6::mCherry reporter (arrow), not the endosomal lumen. *p < 0.05 and **p < 0.01 when compared with the vehicle control

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