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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Endothelial damage, vascular bagging and remodeling of the microvascular bed in human microangiopathy with deep white matter lesions

Fig. 9

Quantitative analyses of CD68-positive cells. a-b In pure SVD, the density of parenchymal and perivascular cells is higher in DWMLs compared to the frontoparietal control region, and the same is also true for parenchymal cells quantified in the frontoparietal in-case control area. In SVD associated with VBI, there is a prominent increase in the density of parenchymal and perivascular cells in all white matter areas compared to corresponding control tissue except for perivascular cells in DWMLs. c-d CD68-positive parenchymal cells are significantly enlarged in all areas in SVD + VBI, whereas these changes are less prominent for perivascular cells. Notably, the size of perivascular cells is also significantly higher in DWMLs of SVD + VBI cases compared to DWMLs in pure SVD. * p < 0.05, ** p < 0.01, *** p < 0.001

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