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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Endothelial damage, vascular bagging and remodeling of the microvascular bed in human microangiopathy with deep white matter lesions

Fig. 3

Quantification of vascular bagging (c and f), which was defined as the difference between the diameter of the vessel lumen (a and d) and outer COLL4-positive bag membrane (b and e). In general, vessel diameters are larger and vascular bagging is more severe in the deep white matter (DWM) of frontoparietal areas than in the temporal lobe. a and d Vessel calibers are slightly smaller in the in-case control area of “pure” SVD cases and all white matter areas of SVD + VBI cases in the frontoparietal region compared to NoSVD controls (a), but no differences are seen in the temporal lobe (d). b and e In the frontoparietal region, the outer membrane diameters (measured at the outer border of bags) are significantly higher in DWMLs of “pure” SVD cases than in all other groups studied. In the temporal lobe, the in-case control areas exhibit significantly increased outer membrane diameters in both “pure” SVD and SVD + VBI cases when compared to NoSVD controls (b). c and f In the frontoparietal region, vascular bagging is more severe in SVD (both pure SVD and SVD + VBI) in all regions studied (DWML and in-case control) than in NoSVD cases. Furthermore, in "pure" SVD cases vascular bagging is significantly increased in DWMLs when compared to in-case control areas (c). In the temporal lobe, in-case control areas of SVD cases show a significant increase in vascular bagging when compared to NoSVD control cases, indicating a generalized disease process (f). The “pure” SVD cases were referred to as SVD in the diagrams. * p < 0.05, ** p < 0.01, *** p < 0.001

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