Fig. 1

Example of deep white matter lesion (DWML) in a case with small vessel disease (SVD) in thick sections (a-c). a Pale DWML with unclear boundaries and islands with less pale areas. b-c Insets from (a) show more oligodendrocytes in relatively well-preserved less pale areas compared to severely affected pale areas, and also small vessels (sv). Case 6 (non-hodgkin lymphoma) with “pure” SVD, i.e., this case has only SVD, but no additional vascular brain injury (VBI) resulting from a ischemic or hemorrhagic cerebral infarct. Scale bars: 1000 μm in (a), 200 μm in (b), 100 μm in (c)