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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3

Fig. 4

Striking muscle pathology in aged MATR3WT (lead line 1563) mice. H&E stain of gastrocnemii of a NT at 24.6 months and b MATR3WT from lead line 1563 at 22.7 months. While the NT muscle fibers showed some vacuoles (arrows), the MATR3WT muscle showed striking pathology with abundant subsarcolemmal vacuoles, internalized nuclei (arrow heads), and loss of fiber shape. Scale bar measures 25 μm

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