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Table 2 Univariate and Multivariate analysis of progression free survival (PFS) and Overall survival (OS) among all tumors

From: Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

Variable

Hazard ratio (HR)

95% confidence interval for HR

p-value

Univariate analysis of PFS among all tumors

 Incomplete resection

1.66

0.30–1.17

0.13

 WHO grade3

2.91

1.34–7.26

0.0057

 C11orf95-RELA fusion

0.59

0.29–1.50

0.29

 PFA

3.30

1.69–6.72

0.0004

 1q gain

3.21

1.50–6.48

0.0037

 EZH2 high expression

1.29

0.63–2.67

0.49

 TERT high expression

1.18

0.58–2.42

0.65

 TERT UTSS high methylation

1.42

0.72–2.96

0.32

 Local radiation therapy> = 50Gy

0.73

0.37–1.46

0.37

 Chemotherapy

1.48

0.74–2.90

0.26

Multivariate analysis of PFS among all tumors

 WHO grade3

1.33

0.53–3.66

0.55

 PFA

3.09

1.48–6.81

0.0024

 1q gain

2.79

1.25–5.99

0.014

Univariate analysis of OS among all tumors

 Incomplete resection

2.22

0.17–1.09

0.077

 WHO grade3

6.31

1.84–39.6

0.0017

 C11orf95-RELA fusion

0.46

0.07–1.61

0.25

 PFA

5.47

2.16–16.7

0.0002

 1q gain

1.57

0.51–3.99

0.40

 EZH2 high expression

1.21

0.46–3.21

0.70

 TERT high expression

0.76

0.29–1.94

0.57

 TERT UTSS high methylation

1.90

0.78–5.28

0.16

 Local radiation therapy> = 50Gy

1.22

0.48–3.31

0.68

 Chemotherapy

1.86

0.74–4.62

0.18

Multivariate analysis of OS among all tumors

 WHO grade3

3.49

0.91–23.05

0.07

 PFA

3.54

1.33–11.4

0.01