Fig. 4

Prediction of PF-EPN subgroups using methylation thresholds of CRIP1, DRD4, and LBX2. a Methylation percentages for the three genes in the training dataset. b Likelihoods for each subgroup calculated by presuming beta distribution. The long-dashed lines denote thresholds determined by likelihood ratios. c Confusion matrices of prediction with training and validation datasets, according to the rule that classifies a case as PFB if all three genes suggest PFB