Fig. 2

Classification of posterior fossa ependymomas (PF-EPNs) using genome-wide methylation profiling. A heatmap analyzed by 3086 probes which showed high standard deviations (SD > 0.25) on CpG islands for unsupervised hierarchical clustering of 60 centrally-diagnosed posterior fossa ependymomas shows that the tumors are divided into two clusters as PFA and PFB. The following information is indicated below the heatmap: tumor location, a pattern of PF tumor extension, pathological grading, the presence of 1q gain, age at onset, and the DKFZ classifier results