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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

Fig. 3

C9orf72 model zebrafish produce multiple species of DPRs from sense and anti-sense transcripts (a) Schematic of the GFP-DPR fusion protein produced by AUG driven translation. (b) Anti-sense DPRs (predominately ATG-driven) containing full length-GFP-DPR fusion, intermediate GFP-DPR fusion and GFP alone bands are detected in 5dpf embryonic lysates. Non-AUG driven GFP deficient RAN translation DPR are also detected in both 2.2.2 and 2.2.7 transgenic lines (Asterix) (C) Sense Poly(GA) DPRs (exclusively RAN-translation driven) detected in 5dpf embryonic lysates

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