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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats

Fig. 6

Accumulation of phosphorylated TDP-43 and ubiquitin in ChATtTA/UBQLN2P497H rats. a Confocal images of phosphorlated TDP-43 (S403-TDP-43) and UBQLN2 staining in the spinal motor neurons of ChATtTA/UBQLN2P497H rats shows that S403-TDP-43 positive inclusions do not colocalize with accumulated UBQLN2. b Confocal images of ubiquitin and UBQLN2 show that ubiquitin and UBQLN2 inclusions colocalize in P497H but not ChATtTA rats. The arrows point to the colocalized inclusions. Scale bars: 20 μm

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