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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer’s disease

Fig. 6

N-terminal antibodies prevent interruption of hippocampal synaptic plasticity by soluble Aβ-rich brain extract. (a) Asp1 N-terminus specific Aβ antibody, 3D6 (red circles), not the C-terminal-specific antibodies 2G3 + 21F12 (blue diamonds) prevent the AD brain TBS extract (purple traces) from inhibiting LTP. (b) Summary data of antibodies to different Aβ epitopes as to their effect on AD brain TBS extract impairment of LTP (N > 6 recordings for each antibody). (c) N-terminal antibody 3D6 (red circles), not the C-terminal target antibodies, 2G3 + 21F12 (blue diamond) prevent the AD brain extract (purple traces) from facilitating LTD. (d). Summary data of antibodies to different Aβ epitopes as to their effect on the AD brain extract’s facilitation of LTD (N > 5 recordings for each antibody). *: p < 0.05; **: p < 0.01

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