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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Satellite cells maintain regenerative capacity but fail to repair disease-associated muscle damage in mice with Pompe disease

Fig. 3

Satellite cells are increased in number but are only transiently activated during disease progression in Gaa−/− limb muscle. a. pax7 expression. Immunofluorescent (IF) staining of TA sections using a Pax7 antibody (in red). Representative images are shown. The basal lamina was stained using a Laminin antibody (in green). Nuclei were stained with Hoechst (in blue). Black and white images of Pax7 staining are also shown for better visualization. Zooms of selected areas (white squares) are shown below the entire sections. b. Quantification of the number of Pax7-positive cells/mm2 from A. Data are means ± SD from 2 muscles derived from 2 different animals per genotype per timepoint. *p < 0.05. **p < 0.01 and ***p < 0.001. c. Quantification of the number of Pax7/Ki67 double-positive cells by immunofluorescent staining of TA sections using Pax7 and Ki67 antibodies. Representative stainings are shown in Additional file 5: Figure S5. Data represent means ± SD from 2 TA muscles derived from 2 different animals. *p < 0.05

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