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Table 1 Clinical, genetic and pathologic characteristics of participants

From: Variation in TMEM106B in chronic traumatic encephalopathy

  Controls
(n = 376)
CTE cases
(n = 86)
P Value
Age (mean ± SD (range)) 61.02 ± 10.2 (35–90) 57.02 ± 21.19 (17–89) 0.01
Years of exposure (mean ± SD (range)) 13.49 ± 5.47 (1–31)
Cases with dementia (%) 33 (38.4%)
TMEM106B MAF 43.2% 41.9% 0.71
rs3173615 genotypes    0.74
 CC (%) 123 (32.7%) 29 (33.7%)  
 CG (%) 181 (48.1%) 42 (48.8%)  
 GG (%) 72 (19.1%) 15 (17.4%)  
CERAD (mean ± SD) 0.29 ± 0.50
Cases with TDP-43 (%) 27 (31.4%)
AT8 Quartiles (positive pixel density/mm2 ± SD)  
 1 283 ± 221  
 2 2863 ± 1362  
 3 10,438 ± 3715  
 4 65,914 ± 62,629  
CD68 Quartiles (Positive cell/mm2 ± SD)
 1 93 ± 15  
 2 138 ± 10  
 3 171 ± 10  
 4 226 ± 31  
  1. CERAD Consortium to establish a registry for Alzheimer’s disease, CTE Chronic Traumatic Encephalopathy (Ranges from Stage I-IV), MAF minor allele frequency