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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model

Fig. 6

Inhibition of TNF-α reduces RGC apoptosis in ephrinB1-Fc-injected retinas. a, Representative TUNEL staining images of RGC apoptosis in normal saline-injected (control) (a), ephrinB1-Fc-injected (b), and ephrinB1-Fc plus Xpro1595-injected (c) whole flat-mounted retinas on 7 d after the injections in the regions at angle 0°. Scale bar, 50 μm, for all the images. b, Bar chart showing the average number of TUNEL-positive cells in whole flat-mounted retinas under different conditions. XPro1595 (50 μg/μl, 2 μl) was pre-injected 1 d before the ephrinB1-Fc injection. n = 5 for all groups. *P < 0.05 and ***P < 0.001 vs. control; #P < 0.05 vs. ephrinB1-Fc alone group

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