Fig. 8
From: Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer’s disease
Hypothetical model of Musashi protein aggregation and its interaction with tau oligomers in AD pathology. The dotted area (left) depicts nuclear-cytoplasmic shuttling of Musashi proteins and their localization in RNA granules based on the published literatures. Additionally, tau protein has also been reported to be involved in RNA granule trafficking. The area under solid line (right) depicts the observations made in this study. Musashi proteins co-localized with tau protein, as well as its oligomeric forms in the cytoplasm. In diseased state, these two proteins might be present in the stress granules. Moreover, mislocalization of tau protein in the nucleus and its subsequent interaction with Musashi proteins may lead to impaired functioning of Musashi proteins, thus resulting in its aggregation