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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer’s disease

Fig. 4

Distinct patterns of MSI2 oligomers in AD brain (a) Representative confocal images of AD cortex stained with α-Oligomer antibody (F11G3, red), α-MSI2 antibody (green) and DAPI (blue) for nuclei (white scale bar: 5 μm, magnification: 63X). (b) Confocal orthogonal view of image (showed in A) showing the presence of MSI2 oligomers in the perinuclear area. (c) Co-localization pixel map between MSI2 (green) and oligomer (red) signals confirmed the overlapping of the two signals (grey area delimitated by green dashed line, white scale bar: 5 μm). (d) Confocal (Z-stacks) image demonstrated punctate MSI2 (inset 1) and more diffused distribution of its oligomers (inset 2) in two different cells (white scale bar: 5 μm). (e-1) Twice zoomed (inset 1) image showing a proximal localization of punctate MSI2 protein to the nucleus. (e-2) Twice zoomed (inset 2) image showing distant localization of MSI2 oligomers from the nucleus (the gap between nucleus and MSI2 oligomers is delimitated by green dashed line)

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