Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location

Table 2 Contingency table of samples used for methylation profiling

Tumor location	Histone H3 mutational status				PDGFRA subgroup	MYCN subgroup	Total number of samples
Tumor location	H3.3-G34R	H3.1-K27M	H3.3-K27M	H3.2-K27M	PDGFRA subgroup	MYCN subgroup	Total number of samples
Cortex	10	0	0	0	10	10	30
Pons	0	12	19	1	0	0	32
Thalamic midline	0	1	17	0	0	0	18

Eighty high grade gliomas were analyzed by 450 k and EPIC Illumina bead arrays. Tumor location and histone H3 mutations or PDGFRA and MYCN molecular subgroups were considered for sample stratification

ISSN: 2051-5960