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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location

Fig. 5

a-b H3K27me3 ChIP-seq signal at promoter regions of upregulated (a) and downregulated (b) genes between H3.1- and H3.3-K27M GSCs (adjusted p-value < 0.01). The average occupancy is centered on TSS and extended 10 kb upstream and downstream (− 10 kb and + 10 kb, respectively). Blue color scale bar indicates relative coverage. c-e H3K27me3 levels found at the loci of selected genes showing increased (OLIG2 and HOXD8) or decreased (SLFN11) mark deposition in H3.1-K27M. Read coverage around the genes of interest is represented in RPKM and gene structure from Ensembl database is shown below. f-h Expression level in tpm of OLIG2, SLFN11 and HOXD8 measured by RNA-seq in GSCs

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