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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location

Fig. 3

Subclassification of DIPG based on RNA-seq, methylome and H3K27me3 epigenetic profiles. a Heatmap and hierarchical clustering of the Pearson correlation matrix of 19 DIPG and 8 matched GSC cultures (H3.3-K27M and H3.1-K27M in light and dark green respectively) across 3209 probes used for DNA methylation measurements. b t-SNE analysis of RNA-seq data in DIPG. RNA sequencing of 21 DIPG samples was performed and the genes associated with the highest standard deviation (n = 250) were selected to conduct t-SNE analysis. The tumors were color-coded according to histone H3 mutated, i.e. H3.3-K27M in light green and H3.1-K27M in dark green. c Principal component analysis of 3 H3.1- and 3 H3.3-K27M GSC models of DIPG based on H3K27me3 epigenetic mark profiling (n = 16,977 genomic intervals)

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