Skip to main content
Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

Fig. 1

GPNMB mRNA expression increases in an age- and dose-dependent manner in some Alzheimer’s disease mouse models. (a) Cerebral GPNMB mRNA levels increased in an age-dependent manner in APP/PS1KI compared to PS1KI control mice. (b) In 5XFAD mice, levels of GPNMB mRNA started to be significantly increased at 7 months of age when compared to wild-type (WT) control mice. 12-month-old 5XFAD mice showed even higher GPNMB levels. (c) In 12-month-old APP23 mice, GPNMB gene expression levels were not increased compared to WT animals. All data are given as mean ± SD. ***P < 0.001; **P < 0.01; *P < 0.05

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us