Skip to main content

Table 8 Morphology of CT100(I716F)-overexpressing DG granule cells

From: NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

GluN1fl/fl

Spine numbers

Control (n = 51)

CT100(I716F) (n = 20)

GluN1−/− (n = 22)

GluN1−/− + CT100(I716F) (n = 28)

 
 

1.7 [1.45–1.97]

1.96 [1.69–2.27]

1.46 [1.16–1.72]

1.51 [1.23–1.98]

Kruskal-Wallis: p = 0.0008; Dunn’s posttest: control vs CT100 p = 0.1308 control vs GluN1−/− p = 0.0381; GluN1−/− vs GluN1−/− + CT100 p > 0.99

Total dendritic length [μm]

Control (n = 15)

CT100(I716F) (n = 27)

GluN1−/− (n = 17)

GluN1−/− + CT100(I716F) (n = 22)

 
 

2106 [1843–2325]

2155 [2018–2533]

2090 [1782–2418]

2019 [1495–2343]

Kruskal-Wallis: p = 0.0195; Dunn’s posttest: control vs CT100 p > 0.99 control vs GluN1−/− p > 0.99; GluN1−/− vs GluN1−/− + CT100 p > 0.99

GluN2Afl/fl

Spine numbers

Control (n = 11)

CT100(I716F) (n = 17)

GluN2A−/−(n = 26)

GluN2A−/− + CT100(I716F) (n = 21)

 
 

1.81 [1.56–1.09]

2.97 [1.84–2.25]

1.65 [1.42–1.95]

1.67 [1.46–1.96]

Kruskal-Wallis: p = 0.0015; Dunn’s posttest: control vs CT100 p = 0.3366 control vs GluN2A−/− p = 0.5077; GluN2A−/− vs GluN2A−/− + CT100 p > 0.9999

Total dendritic length [μm]

Control (n = 16)

CT100(I716F) (n = 17)

GluN2A−/−(n = 17)

GluN2A−/− + CT100(I716F) (n = 18)

 
 

2162 [1657–2391]

1889 [1577–2155]

1862 [1528–2254]

2046 [1885–2189]

Kruskal-Wallis: p = 0.337; Dunn’s posttest: control vs CT100 p = 0.5642 control vs GluN2A−/− p = 0.6218; GluN2A−/− vs GluN2A−/− + CT100 p = 0.6027

GluN2Bfl/fl

Spine numbers

Control (n = 31)

CT100(I716F) (n = 45)

GluN2B−/−(n = 29)

GluN2B−/− + CT100(I716F) (n = 16)

 
 

1.91 [1.8–2.2]

1.88 [1.65–2.13]

1.63 [1.29–2.06]

1.55 [1.18–1.87]

Kruskal-Wallis: p = 0.0021; Dunn’s posttest: control vs CT100 p = 0.7884 control vs GluN2B−/− p = 0.0151; GluN2B−/− vs GluN2B−/− + CT100 p > 0.99

Total dendritic length [μm]

Control (n = 29)

CT100(I716F) (n = 26)

GluN2B−/−(n = 23)

GluN2B−/− + CT100(I716F) (n = 16)

 
 

2248 [2013–2577]

2223 [1882–2364]

2336 [2064–2681]

1882 [1668–2437]

Kruskal-Wallis: p = 0.1092; Dunn’s posttest: control vs CT100 p = 0.6198 control vs GluN2B−/− p > 0.9999; GluN2B−/− vs GluN2B−/− + CT100 p = 0.1049