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Table 8 Morphology of CT100(I716F)-overexpressing DG granule cells

From: NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

GluN1fl/fl
Spine numbers Control (n = 51) CT100(I716F) (n = 20) GluN1−/− (n = 22) GluN1−/− + CT100(I716F) (n = 28)  
  1.7 [1.45–1.97] 1.96 [1.69–2.27] 1.46 [1.16–1.72] 1.51 [1.23–1.98] Kruskal-Wallis: p = 0.0008; Dunn’s posttest: control vs CT100 p = 0.1308 control vs GluN1−/− p = 0.0381; GluN1−/− vs GluN1−/− + CT100 p > 0.99
Total dendritic length [μm] Control (n = 15) CT100(I716F) (n = 27) GluN1−/− (n = 17) GluN1−/− + CT100(I716F) (n = 22)  
  2106 [1843–2325] 2155 [2018–2533] 2090 [1782–2418] 2019 [1495–2343] Kruskal-Wallis: p = 0.0195; Dunn’s posttest: control vs CT100 p > 0.99 control vs GluN1−/− p > 0.99; GluN1−/− vs GluN1−/− + CT100 p > 0.99
GluN2Afl/fl
Spine numbers Control (n = 11) CT100(I716F) (n = 17) GluN2A−/−(n = 26) GluN2A−/− + CT100(I716F) (n = 21)  
  1.81 [1.56–1.09] 2.97 [1.84–2.25] 1.65 [1.42–1.95] 1.67 [1.46–1.96] Kruskal-Wallis: p = 0.0015; Dunn’s posttest: control vs CT100 p = 0.3366 control vs GluN2A−/− p = 0.5077; GluN2A−/− vs GluN2A−/− + CT100 p > 0.9999
Total dendritic length [μm] Control (n = 16) CT100(I716F) (n = 17) GluN2A−/−(n = 17) GluN2A−/− + CT100(I716F) (n = 18)  
  2162 [1657–2391] 1889 [1577–2155] 1862 [1528–2254] 2046 [1885–2189] Kruskal-Wallis: p = 0.337; Dunn’s posttest: control vs CT100 p = 0.5642 control vs GluN2A−/− p = 0.6218; GluN2A−/− vs GluN2A−/− + CT100 p = 0.6027
GluN2Bfl/fl
Spine numbers Control (n = 31) CT100(I716F) (n = 45) GluN2B−/−(n = 29) GluN2B−/− + CT100(I716F) (n = 16)  
  1.91 [1.8–2.2] 1.88 [1.65–2.13] 1.63 [1.29–2.06] 1.55 [1.18–1.87] Kruskal-Wallis: p = 0.0021; Dunn’s posttest: control vs CT100 p = 0.7884 control vs GluN2B−/− p = 0.0151; GluN2B−/− vs GluN2B−/− + CT100 p > 0.99
Total dendritic length [μm] Control (n = 29) CT100(I716F) (n = 26) GluN2B−/−(n = 23) GluN2B−/− + CT100(I716F) (n = 16)  
  2248 [2013–2577] 2223 [1882–2364] 2336 [2064–2681] 1882 [1668–2437] Kruskal-Wallis: p = 0.1092; Dunn’s posttest: control vs CT100 p = 0.6198 control vs GluN2B−/− p > 0.9999; GluN2B−/− vs GluN2B−/− + CT100 p = 0.1049