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Table 5 mEPSC recordings of CT100(I716F)-overexpressing DG granule cells

From: NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

GluN1fl/fl Control (n = 26) CT100(I716F) (n = 33) GluN1−/− (n = 24) GluN1−/− + CT100(I716F) (n = 21)  
Frequency [Hz] 0.66 [0.52–0.77] 0.42 [0.3–0.64] 0.89 [0.69–1.63] 1.02 [0.68–1.23] Kruskal-Wallis: p < 0.0001; Dunn’s posttest: control vs CT100(I716F) p = 0.029; control vs GluN1−/− p = 0.044; GluN1−/− vs GluN1−/− + CT100(I716F) p > 0.99
Percentual reduction   0.36 [0.02–0.55]   −0.15 [− 0.38–0.23] p = 0.0137
Amplitude [pA] 10.81 [10.03–11.47] 10.62 [10.02–11.13] 11.2 [10.34–12.44] 11.05 [9.78–12] Kruskal-Wallis: p = 0.3076; Dunn’s posttest: control vs CT100(I716F) p > 0.99; control vs GluN1−/− p = 0.75; GluN1−/− vs GluN1−/− + CT100(I716F) p > 0.99
GluN2Afl/fl Control (n= 36) CT100(I716F) (n= 37) GluN2A−/− (n= 24) GluN2A−/− + CT100(I716F) (n= 19)  
Frequency [Hz] 0.61 [0.5–0.75] 0.5 [0.31–0.68] 0.76 [0.6–0.92] 0.62 [0.46–0.85] Kruskal-Wallis: p = 0.0004; Dunn’s posttest: control vs CT100(I716F) p = 0.0468; control vs GluN2A−/− p = 0.149; GluN2A−/− vs GluN2A−/− + CT100(I716F) p = 0.485
Percentual reduction   0.19 [− 0.1–0.51]   0.18 [− 0.11–0.39] p = 0.27
Amplitude [pA] 9.67 [8.46–10.32] 9.83 [9.3–10.82] 10.47 [9.29–12.96] 10.44 [9.84–11.95] Kruskal-Wallis: p = 0.013; Dunn’s posttest: control vs CT100(I716F) p = 0.844; control vs GluN2A−/− p = 0.75; GluN2A−/− vs GluN2A−/− + CT100(I716F) p > 0.99
GluN2Bfl/fl Control (n = 28) CT100(I716F) (n= 25) GluN2B−/− (n = 27) GluN2B−/− + CT100(I716F) (n = 26)  
Frequency [Hz] 0.71 [0.53–1.08] 0.39 [0.28–0.75] 1.01 [0.81–1.23] 0.87 [0.72–1.03] Kruskal-Wallis: p < 0.0001; Dunn’s posttest: control vs CT100(I716F) p = 0.013; control vs GluN2B−/− p = 0.018; GluN2B−/− vs GluN2B−/− + CT100(I716F) p = 0.497
Percentual reduction   0.45 [− 0.06–0.6]   0.14 [− 0.02–0.29] p = 0.1
Amplitude [pA] 9.58 [8.61–10.26] 9.65 [8.43–10.51] 9.8 [9.2–10.61] 11.59 [10.16–12.69] Kruskal-Wallis: p < 0.0001; Dunn’s posttest: control vs CT100(I716F) p > 0.9999; control vs GluN2B−/− p > .0.9999; GluN2B−/− vs GluN2B−/− + CT100(I716F) p = 0.0033