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Table 4 Values for spine morphology in CT100 and CT100(I716F) overexpression experiments

From: NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

  Spine morphology distribution [%]
Stubby Thin Mushroom
9w pi CT100 in P7 floxed GluN1
 Control (23) 0.29 [0.26–0.31] 0.62 [0.6–0.67] 0.09 [0.47–0.11]
 CT100 (6) 0.36 [0.27–0.4] 0.59 [0.54–0.64] 0.06 [0.04–0.09]
 GluN1−/− (10) 0.29 [0.23–0.35] 0.6 [0.57–0.7] 0.07 [0.05–0.1]
 GluN1−/− + CT100 (23) 0.27 [0.23–0.32] 0.64 [0.62–0.67] 0.07 [0.05–0.11]
 Kruskal Wallis test (Dunn’s posttest) P = 0.1972 (Control vs CT100: p = 0.4813 Control vs GluN1−/: p > 0.9999; GluN1−/− vs GluN1−/− + CT100: p > 0.9999) P = 0.1433 (Control vs CT100: p = 0.6288; Control vs GluN1−/: p > 0.9999; GluN1−/− vs GluN1−/− + CT100: p = 0.5863) P = 0.8439 (Control vs CT100: p > 0.9999; Control vs GluN1−/: p > 0.9999; GluN1−/− vs GluN1−/− + CT100: p > 0.9999)
DG granule cells GluN1−/− line
 Control (49) 0.32 [0.27–0.36] 0.61 [0.54–0.64] 0.08 [0.05–0.10]
 CT100(I716F) (19) 0.29 [0.27–0.33] 0.63 [0.59–0.66] 0.08 [0.06–0.08]
 GluN1−/− (22) 0.32 [0.26–0.39] 0.56 [0.49–0.64] 0.1 [0.06–0.14]
 GluN1−/− + CT100(I716F) (28) 0.32 [0.27–0.37] 0.61 [0.55–0.67] 0.07 [0.05–0.85]
 Kruskal Wallis test (Dunn’s posttest) p = 0.529 (Control vs CT100(I716F): p = 0.53; Control vs GluN1−/−: p > 0.9999; GluN1−/− vs GluN1−/− + CT100(I716F): p > 0.9999) p = 0.198 (Control vs CT100(I716F): p = 0.5339; Control vs GluN1−/−: p = 0.8345; GluN1−/− vs GluN1−/− + CT100(I716F): p = 0.3877) p = 0.1098 (Control vs CT100(I716F): p > 0.9999; Control vs GluN1−/−: p = 0.2132; GluN1−/− vs GluN1−/− + CT100(I716F): p = 0.0511)
DG granule cells GluN2Afl/fl line
 Control (11) 0.35 [0.32–0.37] 0.57 [0.53–0.62] 0.08 [0.03–0.11]
 CT100(I716F) (17) 0.36 [0.29–0.38] 0.57 [0.52–0.62] 0.07 [0.06–0.11]
 GluN2A−/− (26) 0.38 [0.34–0.42] 0.54 [0.49–0.58] 0.1 [0.06–0.18]
 GluN2A−/− + CT100(I716F) (21) 0.34 [0.3–0.38] 0.55 [0.52–0.61] 0.1 [0.08–0.13]
 Kruskal Wallis test (Dunn’s posttest) p = 0.1208 (Control vs CT100(I716F): p > 0.999; Control vs GluN1−/−: p = 0.9455; GluN1−/− vs GluN1−/− + CT100(I716F): p = 0.0586) p = 0.2321 (Control vs CT100(I716F): p > 0.9999; Control vs GluN1−/−: p = 0.2893; GluN1−/− vs GluN1−/− + CT100(I716F): p = 0.7813) p > 0.1487 (Control vs CT100(I716F): p > 0.9999; Control vs GluN1−/−: p > 0.9999; GluN1−/− vs GluN1−/− + CT100(I716F): p = 0.4372)
DG granule cells GluN2Bfl/fl line
 Control (31) 0.36 [0.33–0.42] 0.55 [0.49–0.58] 0.08 [0.06–0.11]
 CT100(I716F) (45) 0.32 [0.28–0.4] 0.59 [0.53–0.6442] 0.07 [0.05–0.1]
 GluN2B−/− (29) 0.33 [0.28–0.39] 0.56 [0.49–0.6] 0.11 [0.09–0.14]
 GluN2B−/− + CT100(I716F) (16) 0.37 [0.33–0.44] 0.57 [0.5–0.6] 0.07 [0.04–0.09]
 Kruskal Wallis test (Dunn’s posttest) P = 0.0105 (Control vs CT100(I716F): p = 0.0277; Control vs GluN2B−/−: p = 0.043; GluN2B−/− vs GluN2B−/− + CT100(I716F): p = 0.1063) P = 0.0319 (Control vs CT100(I716F): p = 0.0112; Control vs GluN2B−/−: p = 0.6837; GluN2B−/− vs GluN2B−/− + CT100(I716F): p > 0.9999) P = 0.0002 (Control vs CT100(I716F): p > 0.9999; Control vs GluN2B−/−: p = 0.0066; GluN2B−/− vs GluN2B−/− + CT100(I716F): p = 0.0048)