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Table 2 NMDAR-mediated currents in 5xFAD DG granule cells and virus-infected cells

From: NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

  Control (n = 16) GluN1−/− (n = 15)  
NMDAR/AMPAR ratio 1 ± 0.65 0.13 ± 0.04 MW test: p < 0.0001
  WT (n = 22) 5xFAD (n = 29)  
NMDAR/AMPAR ratio 1.18 [0.79–1.77] 0.72 [0.43–1.2] MW test: p = 0.0029
  WT (n = 18) 5xFAD (n = 25)  
Decay tau [ms] 62.91 [57.75–67.48] 66.51 [59.2–72.86] MW test: p = 0.0969
  WT (n = 23) 5xFAD (n = 22)  
Extrasynaptic amplitude [pA] 125.3 [85.8–178.6] 77.57 [43.12–101.2] MW test: p = 0.0003
  WT (n = 23) 5xFAD (n = 22)  
Deactivation [ms] 74.76 [63.62–88.33] 79.43 [71.22–104.3] MW test: p = 0.1712