Table 2 NMDAR-mediated currents in 5xFAD DG granule cells and virus-infected cells

NMDAR/AMPAR ratio

1 ± 0.65

0.13 ± 0.04

MW test: p < 0.0001

WT (n = 22)

5xFAD (n = 29)

NMDAR/AMPAR ratio

1.18 [0.79–1.77]

0.72 [0.43–1.2]

MW test: p = 0.0029

WT (n = 18)

5xFAD (n = 25)

Decay tau [ms]

62.91 [57.75–67.48]

66.51 [59.2–72.86]

MW test: p = 0.0969

WT (n = 23)

5xFAD (n = 22)

Extrasynaptic amplitude [pA]

125.3 [85.8–178.6]

77.57 [43.12–101.2]

MW test: p = 0.0003

WT (n = 23)

5xFAD (n = 22)

Deactivation [ms]

74.76 [63.62–88.33]

79.43 [71.22–104.3]

MW test: p = 0.1712