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Table 11 Overview of values for spine morphology in 5xFAD mice

From: NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

  Spine Morphology distribution [%]
Stubby Thin Mushroom
6 m 5xFAD DG
 WT (17) 0.31 [0.25–0.34] 0.6 [0.56–0.64] 0.1 [0.06–0.1]
 5xFAD (18) 0.32 [0.27–0.35] 0.58 [0.56–0.61] 0.1 [0.09–0.11]
 Mann-Whitney test p = 0.4 p = 0.142 p = 0.85
1a 5xFAD DG
 WT (29) 0.26 [0.22–0.35] 0.64 [0.6–0.7] 0.08 [0.04–0.11]
 5xFAD (28) 0.32 [0.23–0.38] 0.59 [0.23–0.38] 0.09 [0.06–0.16]
 Mann-Whitney test p = 0.32 p = 0.13 p = 0.14
 GluN1−/− (7) 0.32 [0.27–0.39] 0.56 [0.45–0.62] 0.12 [0.12–0.16]
 5xFAD/GluN21−/− (12) 0.29 [0.25–0.31] 0.57 [0.47–0.63] 0.14 [0.12–0.21]
 Mann-Whitney test p = 0.16 p = 0.526 p = 0.29
 GluN2A−/− (12) 0.31 [0.24–0.36] 0.58 [0.47–0.64] 0.13 [0.09–0.17]
 5xFAD/GluN2A−/− (10) 0.39 [0.32–0.5] 0.39 [0.29–0.46] 0.19 [0.14–0.26]
 Mann-Whitney test p = 0.02 p = 0.002 p = 0.025
 GluN2B−/− (15) 0.35 [0.27–0.4] 0.53 [0.45–0.62] 0.1 [0.08–0.14]
 5xFAD/GluN2B−/− (11) 0.42 [0.34–0.52] 0.47 [0.37–0.54] 0.13 [0.1–0.16]
 Mann-Whitney test p = 0.0362 p = 0.0687 p = 0.3565