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Table 10 mEPSC recordings from the 5xFAD mouse model

From: NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

6 m DG

 

WT (n = 24)

5xFAD (n = 23)

 

Frequency [Hz]

0.73 [0.44–0.91]

0.66 [0.45–1.2]

MW-test: p = 0.6612

Amplitude [pA]

10.08 [9.15–10.52]

10.64 [10.15–11.7]

MW-test: p = 0.0013

1a DG

 

WT (n = 27)

5xFAD (n = 21)

 

Frequency [Hz]

0.80 [0.61–1.07]

0.61 [0.44–0.89]

MW-test: p = 0.026

Amplitude [pA]

10.44 [8.54–11.95]

11.2 [8.94–11.86]

MW-test: p = 0.47

 

GluN1−/− (n = 17)

5xFAD/ GluN1−/− (n = 17)

 

Frequency [Hz]

0.85 [0.68–1.26]

1.02 [0.55–1.56]

MW-test: p = 0.8119

Amplitude [pA]

11.2 [10.24–12.84]

10.43 [9.66–12.31]

MW-test: p = 0.394

 

GluN2A−/− (n = 23)

5xFAD/ GluN2A−/− (n = 17)

 

Frequency [Hz]

0.97 [0.61–1.13]

1.01 [0.64–1.98]

MW-test: p = 0.2802

Amplitude [pA]

9.0 [8.38–9.93]

9.45 [8.97–10.72]

MW-test: p = 0.1626

 

GluN2B−/− (n = 21)

5xFAD/ GluN2B−/− (n = 16)

 

Frequency [Hz]

1.26 [0.89–1.61]

1.31 [0.6–1.63]

MW-test: p > 0.999

Amplitude [pA]

11.63 [10.72–12.14]

10.06 [9.88–12.92]

MW-test: p = 0.3232