Fig. 4

The amplitude of synaptic and extrasynaptic NMDAR-mediated currents is reduced in 5xFAD mice. a Example traces of NMDAR- and AMPAR-mediated currents recorded at holding potential of − 70 mV and + 40 mV, respectively, in DG granule cells of WT and 5xFAD mice. b The NMDAR/AMPAR (N/A) ratio is significantly reduced in DG granule cells of 5xFAD mice. c Example traces of NMDAR-mediated currents recorded at -30 mV. d The time constant of decay currents is not different between WT and 5xFAD cells. e Example traces of extrasynaptic NMDAR-mediated currents evoked by ultrafast-application of glutamate onto nucleated patches. f The peak amplitude of NMDAR-mediated currents is significantly reduced in granule cells of 5xFAD mice. g Example traces of normalized extrasynaptic NMDAR-mediated currents. h There is no difference in the deactivation time constant between DG granule cells of WT and 5xFAD mice. Bar graphs show median ± IQR. * = p < 0.05, ** = p < 0.01, *** = p < 0.001, ampl. = amplitude, deact. = deactivation