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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis

Fig. 9

Cell motility is altered in HeLa cells overexpressing mutant ADGRL2. a Wound healing experiments were performed on monolayer HeLa cells overexpressing pcD-empty, CIRL2-Wt or CIRL2-Mt. Microphotographs visualize wound healing images acquired 0 and 72 h after the scratch. b Time-course quantification of scratch width in monolayer HeLa cells overexpressing pcD-empty, CIRL2-Wt or CIRL2-Mt. Each value represents the mean (±S.E.M.) from three independent experiments. **, p < 0.01; ***, p < 0.001; ****, p < 0.0001 using two-way ANOVA test

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