Fig. 7

Main representative images and quantitative findings obtained from MRI performed in Adgrl2^+/+ and Adgrl2^+/− male and female adult mouse brains. a-b Horizontal T2-weighted images passing through the mesencephalon of Adgrl2^+/+ mice. a revealing in Adgrl2^+/− mice b a defect in tectum growth with insufficiently developed colliculi (red arrow) and pes pedunculi (blue arrow) with a growth defect of the telencephalon (line corresponding to bi-parietal diameter) responsible for a vacuo ventricular dilatation (asterisk), and of the cerebellum (line corresponding to transverse diameter) with smaller cerebellar hemispheres (white arrows). c T2-weighted images passing through the optic chiasm in Adgrl2^+/+ mice. d Deficient frontal growth in Adgrl2^+/− mice (thick line). e Schematic representation of the different measurements performed on Adgrl2^+/+ and Adgrl2^+/− male and female adult mouse vermis (height in green, anterior-posterior diameter in red, and area in yellow) revealing no difference in heights in Adgrl2^+/+ and Adgrl2^+/− females compared to males (f), whereas significant differences in anterior-posterior diameters were apparent both in females and males (g), but with significant differences in vermis areas between Adgrl2^+/+ and Adgrl2^+/− female mice only contrary to Adgrl2^+/+ and Adgrl2^+/− males (h)