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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis

Fig. 5

ADGRL2 immunohistochemistry in the normal developing human brain. a Strong immunoreactivity of stem cells in the VZ and of intermediate progenitors in the SVZ, as well as in several migrating neurons (arrow) [OM × 100]. b Immunopositivity of LGE at 18WG [OM × 25]. c 18WG onward positive Cajal-Retzius cells in layer I (thick arrow) and cortical neurones (arrow head) [OM × 250]. d Immunoreactive differentiating pyramidal neurons of the layers III and V [OM × 25]. e Intense immunolabelling of the developing cerebellum at 6PCW, predominating in the ventricular zone (thick arrow) and in the choroid plexuses (arrow head) [OM × 25]. f At 24WG, strong immunoreactivity of the transient external granular cell layer and in Purkinje cells (arrow), but with no positivity in the developing internal granular cell layer [OM × 250]. g Only positive Golgi II neurons at 32WG in the internal granular cell layer (arrow head), Purkinje cells remaining strongly immunoreactive (thick arrow) [OM × 400]. h Diffuse neuronal immunoreactivity in the olivary nuclei from 25WG [OM × 25]. OM: original magnification; VZ: ventricular zone; SVZ: subventricular zone; CN: caudate nucleus; LGE: lateral ganglionic eminences; C: cerebellum; Rh: rhombencephalon; EGL: external granular cell layer of the cerebellar cortex; M: molecular layer; LD: lamina dissecans; IGL: internal granular cell layer of the cerebellar cortex, ON: olivary nucleus

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