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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Satellite cells fail to contribute to muscle repair but are functional in Pompe disease (glycogenosis type II)

Fig. 9

Similar muscle regenerative process in Gaa−/− and WT mice following acute injury. a: Hematoxylin-Eosin-Saffron (HES) staining of Tibialis anterior (TA) muscle sections “Discussion”, 7 and 21 days after injury (dpi) induced by cardiotoxin (CTX) injection. Arrows and arrowheads indicate necrotic fibers and newly formed myofibers, respectively. Insert indicates necrotic fibers. b: Quantification of macrophage infiltration at 4 and 7 dpi based on F4/80 immunolabeling. c: Minimal Feret diameter of muscle fibers from Gaa−/− and WT mice at 21 dpi. d: Distribution of TA muscle fibers from Gaa−/− and WT mice based on their minimal Feret diameter. e: Number of satellite cells (Pax7+ cells) at 4, 7 and 21 dpi. F: Number of differentiated myoblasts (MyoG+ cells) at 4, 7 and 21 dpi. Scale bars = 100 μm. Statistics: Two-way ANOVA with Sidak post hoc test; n = 5 animals per group; *p < 0.05

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