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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Satellite cells fail to contribute to muscle repair but are functional in Pompe disease (glycogenosis type II)

Fig. 3

Structural abnormalities in skeletal muscle from Gaa−/− mice and autophagic buildup over the disease course. a: Serial cross-sections of Tibialis anterior (TA) and Triceps brachii (TB) muscles stained with Hematoxylin-Eosin-Saffron (HES) and immunolabeled with anti-LC3 (green) and anti-dystrophin (red) antibodies. Nuclei are counterstained with DRAQ5 (blue). b: Quantification of autophagic buildup in fibers from TA and TB muscles. c: Quantification of the size of the LC3+-aggregates in TA and TB muscle fibers. Scale bars = 50 μm. Statistics: One-way ANOVA with Sidak post hoc test; n = 5 animals per group; *p < 0.05; **p < 0.01; ***p < 0.001

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