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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Detection of tau in Gerstmann-Sträussler-Scheinker disease (PRNP F198S) by [18F]Flortaucipir PET

Fig. 7

Comparison of AT8 and PHF-1 Staining to [18F]Flortaucipir in the Moderately to Severely Impaired GSS Patient B. Good correspondence between the [18F]flortaucipir SUVR (3rd column) and both the AT8 (1st column) and PHF-1 (2nd column) immunolabeling of tau and neurofibrillary tangles, respectively, was observed across the basal ganglia and cingulate gyrus (a-c), as well as the frontal (a-d) and insular cortices (b,c,d). However, while the AT8 immunolabeling was more widespread throughout the cortical and subcortical regions, the PHF-1 immunolabeling was more restricted to areas that corresponded to increased [18F]flortaucipir signal, with the exception of the thalamus

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