Fig. 5

Neuropathologic Analysis of the Moderately to Severely Impaired GSS Patient B. Good correspondence between the [¹⁸F]flortaucipir SUVR (5th column) and AT8 immunolabeling of tau (4th column) was observed across multiple regions, including the basal ganglia and cingulate gyrus (a-c), as well as the frontal (a-d) and insular cortices (b,c,d). These areas also feature considerable structural atrophy on MRI (1st column) and LFB-H&E stain (2nd column), as well as PrP amyloid deposition on 3F4 (3rd column). The only region of non-correspondence occurred in the thalamus (d), where [¹⁸F]flortaucipir PET (5th column) showed increased uptake but no AT8 immunolabeling of tau (4th column) was observed; PrP deposition was observed in the thalamus (3rd column). LFB-H&E = luxol fast blue with hematoxylin & eosin; MRI = magnetic resonance imaging; PrP = prion protein