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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

Fig. 5

Inhibition of STAT3-mediated astrocyte reactivity improves spatial learning in APP mice a, Training phase of the Morris water maze. APP-GFP mice (N = 12) need more trials to learn the task than WT-GFP mice (N = 11). This learning deficit is corrected by SOCS3 expression in APP astrocytes (N = 11). Repeated-measures ANOVA. b, Probe phase of the Morris Water maze, 72 h after the last training session. Unlike WT-GFP mice, APP-GFP mice do not display preference for the target quadrant (T) over other quadrants (O). This memory deficit is not corrected by SOCS3. Wilcoxon test. * p < 0.05

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