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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

Fig. 3

SOCS3 inhibits the expression of reactive astrocyte markers. a, Heatmaps of genes belonging to the pan, A1 or A2 reactive astrocyte cassettes. SOCS3 decreases the expression of markers belonging to all categories, in APP astrocytes. Color scales represent mean-centered expression (log2-transformed). Wald test. b, Dendrogram obtained by WGCNA with the significant module indicated with an arrow. c, The significant WGCNA module is mainly formed by genes down-regulated by SOCS3. ANOVA. N = 7-4-5. * p < 0.05, ** p < 0.01, *** p < 0.001

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