Table 2 Pharmacokinetic analysis of ACY-1215
ACY-1215 plasma concentration | ACY-1215 Brain concentration | Brain to plasma ration | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Dose (mg/kg) | Dose route | Sampling time (hr) | Mean (ng/mL) | SD | CV (%) | Mean (ng/g) | SD | CV (%) | Mean | SD | CV (%) |
30 | Oral | Predose | BQL | N/A | N/A | NA | NA | NA | BQL | NA | NA |
0.5 | 1226.67 | 63.51 | 5.18 | 15.20 | 3.65 | 24.01 | 0.01 | 0.00 | 27.61 | ||
1 | 561.00 | 128.36 | 22.88 | 5.61 | NA | NA | NA | NA | NA | ||
4 | 60.60 | 26.63 | 43.94 | BQL | NA | NA | NA | NA | NA | ||
8 | 18.02 | 9.78 | 54.29 | BQL | NA | NA | NA | NA | NA | ||