Table 1 Pharmacokinetic analysis of ACY-1083
ACY-1083 plasma concentration | ACY-1083 Brain concentration | Brain to plasma ration | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Dose (mg/kg) | Dose route | Sampling time (hr) | Mean (ng/mL) | SD | CV (%) | Mean (ng/g) | SD | CV (%) | Mean | SD | CV (%) |
5 | IP | Predose | NA | NA | NA | NA | NA | NA | BQL | NA | NA |
0.08 | 654.33 | 58.71 | 8.97 | 44.13 | 11.68 | 26.46 | 0.07 | 0.01 | 18.72 | ||
0.25 | 936.00 | 91.43 | 9.77 | 109.50 | 10.26 | 9.37 | 0.12 | 0.01 | 4.27 | ||
1 | 180.00 | 11.00 | 6.11 | 112.33 | 8.08 | 7.20 | 0.63 | 0.08 | 13.33 | ||
4 | 78.30 | 7.39 | 9.44 | 15.17 | 2.41 | 15.88 | 0.20 | 0.04 | 22.38 | ||