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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment

Fig. 2

Effect of the brain-penetrating HDAC6 inhibitor ACY-1083 on cisplatin-induced cognitive impairment in the NOPR and puzzle box tests. Mice were treated with two 5-day cycles of cisplatin or PBS, followed by 14 daily administrations of ACY-1083. a The NOPR test was performed 1 week after the last injection of ACY-1083 and the discrimination index was calculated (n = 8–9; two-way ANOVA with Tukey’s post-hoc analysis: F (1, 30) = 6.3; PBS vs. Cisplatin, p = 0.0076; Cisplatin vs. Cisplatin + ACY-1083, p = 0.0223). b Total investigation time of both objects in the NOPR was recorded (n = 8–9; two-way ANOVA, (F (1, 31) = 0.6425, p = 0.4289), stacked columns were used to indicate time of interaction with the novel and the familiar object. c The puzzle box was performed 2 weeks after the last injection of ACY-1083. During trials 1–4, the underpass was unobstructed; during trials 5–7, the underpass was filled with corncob bedding; during trials 8–11, the underpass was covered by the cardboard plug. The time it took for mice to enter the goal box was recorded (n = 10–14; two-way ANOVA with Tukey’s post-hoc analysis: F (30, 407) = 5.698; PBS vs. Cisplatin, p < 0.0001; Cisplatin vs. Cisplatin + ACY-1083, p < 0.0001). Results are expressed as mean ± SEM; *p < 0.05, **p < 0.01, ****p < 0.0001

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