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Table 1 Interventions and outcomes for patients treated at SJCRH

From: Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis

No.

CSF diversion

(no. of revision[s])

Ommaya

Surgery

Chemotherapy

RT

Indication for adjuvant

Long-term sequelae

Outcome

Duration of follow-up (y)

1

VPS (1)

No

Bx upfront

Nil

54 Gy

Upfront

Seizure; memory issues

Alive with SD

12.67

2

VPS (6)

No

Bx at progression, then repeated drainage of cyst; and GTR × 2

POG9060 (ifosfamide)

55.8 Gy

Multiple PD

Learning difficulties

Died of shunt failure

6.78

3

VPS (subdural)

No

Nil

Nil

Nil

N/A

HA + diplopia

Died of obstructive hydrocephalus

7.72

4

VPS (12) → ETV (1)

No

Nil

Carboplatin + tamoxifen

Nil

PD

HA, N, V, nystagmus, OA, VF defect, R CN VII deficit, hypopituitarism

Died of suicide

10.72

5

VPS (subdural)

No

Nil

Nil

Nil

N/A

Nil

Alive with SD

16.98

6

VPS

No

Nil

Nil

Nil

N/A

Spastic quadriplegic CP, epilepsy, severe mental retardation,

Alive with SD

13.97

7

VPS (2)

No

Bx upfront, then resection of spinal metastasis at progression

1. Carboplatin + vincristine + temozolomide

2. Lomustine + procarbazine + vincristine

Nil

PD (metastasis)

GHD, epilepsy off medications

Alive with SD

11.24

8

Nil

No

Nil

 

Nil

N/A

Migraine

Alive with SD

11.28

9

ETV → VPS at progression

No

Bx upfront, resection at progression (complicated by hemorrhagic stroke)

Nil

54 Gy

Upfront

L hemiparesis, bilateral CN IV and VI palsy

Alive with NED

10.31

10

ETV → VPS (1)

Yes

Bx at progression

1. Carboplatin + vincristine + temozolomide

2. Vinblastine

3. Selumetinib

Nil

PD (metastasis)

HA

Alive with SD on treatment

9.37

11

VPS (2)

No

Bx upfront inconclusive;

2 more Bxs at progression

Nil

54 Gy

RT necrosis requiring steroid/bevacizumab

PD

Pathological fracture due to steroid use

Alive with SD

9.57

12

Nil

No

Nil

Nil

54 Gy

PD

Headache, L ptosis, xerostomia, ADHD

Alive with SD

7.56

13

VPS (2)

No

Nil

Nil

Nil

N/A

Seizure, bilateral exotropia, delay, learning difficulty, NF-1 related

Alive with SD

9.81

14

ETV

Yes

Nil

Nil

Nil

N/A

Nil

Alive with SD

5.46

15

ETV

Yes

Nil

Nil

Nil

N/A

Intermittent exotropia bilaterally

Alive with SD

5.81

16

Nil

No

Nil

Nil

Nil

N/A

Migraine

Alive with SD

4.94

17

ETV

Yes

Nil

Nil

Nil

N/A

Memory problem, NF-1 related

Alive with SD

4.51

18

ETV

Yes

Nil

Nil

Nil

N/A

HA? Migraine

Alive with SD

3.64

19

ETV

Yes

Nil

Nil

Nil

N/A

Abnormal EEG

Alive with SD

1.49

20

ETV

Yes

Nil

Nil

Nil

N/A

Nil

Alive with SD

1.49

21

ETV

Yes

Nil

Nil

Nil

N/A

Nil

Alive with SD

1.24

22

ETV

No

Bx upfront

Nil

Nil

N/A

Nil

Alive with SD

0.51

  1. ADHD attention-deficit hyperactivity disorder, Bx biopsy, CP cerebral palsy, CSF cerebrospinal fluid, CN cranial nerve, ETV endoscopic third ventriculostomy, GHD growth hormone deficiency, GTR gross total resection, HA headache, L left, N nausea, NF-1 neurofibromatosis type 1, OA optic atrophy, PD progressive disease, R right, RT radiotherapy, SD stable disease, V vomiting, VF visual field, VPS ventriculo-peritoneal shunt, y year(s)