No. | CSF diversion (no. of revision[s]) | Ommaya | Surgery | Chemotherapy | RT | Indication for adjuvant | Long-term sequelae | Outcome | Duration of follow-up (y) |
---|---|---|---|---|---|---|---|---|---|
1 | VPS (1) | No | Bx upfront | Nil | 54Â Gy | Upfront | Seizure; memory issues | Alive with SD | 12.67 |
2 | VPS (6) | No | Bx at progression, then repeated drainage of cyst; and GTR × 2 | POG9060 (ifosfamide) | 55.8 Gy | Multiple PD | Learning difficulties | Died of shunt failure | 6.78 |
3 | VPS (subdural) | No | Nil | Nil | Nil | N/A | HA + diplopia | Died of obstructive hydrocephalus | 7.72 |
4 | VPS (12) → ETV (1) | No | Nil | Carboplatin + tamoxifen | Nil | PD | HA, N, V, nystagmus, OA, VF defect, R CN VII deficit, hypopituitarism | Died of suicide | 10.72 |
5 | VPS (subdural) | No | Nil | Nil | Nil | N/A | Nil | Alive with SD | 16.98 |
6 | VPS | No | Nil | Nil | Nil | N/A | Spastic quadriplegic CP, epilepsy, severe mental retardation, | Alive with SD | 13.97 |
7 | VPS (2) | No | Bx upfront, then resection of spinal metastasis at progression | 1. Carboplatin + vincristine + temozolomide 2. Lomustine + procarbazine + vincristine | Nil | PD (metastasis) | GHD, epilepsy off medications | Alive with SD | 11.24 |
8 | Nil | No | Nil | Â | Nil | N/A | Migraine | Alive with SD | 11.28 |
9 | ETV → VPS at progression | No | Bx upfront, resection at progression (complicated by hemorrhagic stroke) | Nil | 54 Gy | Upfront | L hemiparesis, bilateral CN IV and VI palsy | Alive with NED | 10.31 |
10 | ETV → VPS (1) | Yes | Bx at progression | 1. Carboplatin + vincristine + temozolomide 2. Vinblastine 3. Selumetinib | Nil | PD (metastasis) | HA | Alive with SD on treatment | 9.37 |
11 | VPS (2) | No | Bx upfront inconclusive; 2 more Bxs at progression | Nil | 54Â Gy RT necrosis requiring steroid/bevacizumab | PD | Pathological fracture due to steroid use | Alive with SD | 9.57 |
12 | Nil | No | Nil | Nil | 54Â Gy | PD | Headache, L ptosis, xerostomia, ADHD | Alive with SD | 7.56 |
13 | VPS (2) | No | Nil | Nil | Nil | N/A | Seizure, bilateral exotropia, delay, learning difficulty, NF-1 related | Alive with SD | 9.81 |
14 | ETV | Yes | Nil | Nil | Nil | N/A | Nil | Alive with SD | 5.46 |
15 | ETV | Yes | Nil | Nil | Nil | N/A | Intermittent exotropia bilaterally | Alive with SD | 5.81 |
16 | Nil | No | Nil | Nil | Nil | N/A | Migraine | Alive with SD | 4.94 |
17 | ETV | Yes | Nil | Nil | Nil | N/A | Memory problem, NF-1 related | Alive with SD | 4.51 |
18 | ETV | Yes | Nil | Nil | Nil | N/A | HA? Migraine | Alive with SD | 3.64 |
19 | ETV | Yes | Nil | Nil | Nil | N/A | Abnormal EEG | Alive with SD | 1.49 |
20 | ETV | Yes | Nil | Nil | Nil | N/A | Nil | Alive with SD | 1.49 |
21 | ETV | Yes | Nil | Nil | Nil | N/A | Nil | Alive with SD | 1.24 |
22 | ETV | No | Bx upfront | Nil | Nil | N/A | Nil | Alive with SD | 0.51 |