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Table 1 Interventions and outcomes for patients treated at SJCRH

From: Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis

No. CSF diversion
(no. of revision[s])
Ommaya Surgery Chemotherapy RT Indication for adjuvant Long-term sequelae Outcome Duration of follow-up (y)
1 VPS (1) No Bx upfront Nil 54 Gy Upfront Seizure; memory issues Alive with SD 12.67
2 VPS (6) No Bx at progression, then repeated drainage of cyst; and GTR × 2 POG9060 (ifosfamide) 55.8 Gy Multiple PD Learning difficulties Died of shunt failure 6.78
3 VPS (subdural) No Nil Nil Nil N/A HA + diplopia Died of obstructive hydrocephalus 7.72
4 VPS (12) → ETV (1) No Nil Carboplatin + tamoxifen Nil PD HA, N, V, nystagmus, OA, VF defect, R CN VII deficit, hypopituitarism Died of suicide 10.72
5 VPS (subdural) No Nil Nil Nil N/A Nil Alive with SD 16.98
6 VPS No Nil Nil Nil N/A Spastic quadriplegic CP, epilepsy, severe mental retardation, Alive with SD 13.97
7 VPS (2) No Bx upfront, then resection of spinal metastasis at progression 1. Carboplatin + vincristine + temozolomide
2. Lomustine + procarbazine + vincristine
Nil PD (metastasis) GHD, epilepsy off medications Alive with SD 11.24
8 Nil No Nil   Nil N/A Migraine Alive with SD 11.28
9 ETV → VPS at progression No Bx upfront, resection at progression (complicated by hemorrhagic stroke) Nil 54 Gy Upfront L hemiparesis, bilateral CN IV and VI palsy Alive with NED 10.31
10 ETV → VPS (1) Yes Bx at progression 1. Carboplatin + vincristine + temozolomide
2. Vinblastine
3. Selumetinib
Nil PD (metastasis) HA Alive with SD on treatment 9.37
11 VPS (2) No Bx upfront inconclusive;
2 more Bxs at progression
Nil 54 Gy
RT necrosis requiring steroid/bevacizumab
PD Pathological fracture due to steroid use Alive with SD 9.57
12 Nil No Nil Nil 54 Gy PD Headache, L ptosis, xerostomia, ADHD Alive with SD 7.56
13 VPS (2) No Nil Nil Nil N/A Seizure, bilateral exotropia, delay, learning difficulty, NF-1 related Alive with SD 9.81
14 ETV Yes Nil Nil Nil N/A Nil Alive with SD 5.46
15 ETV Yes Nil Nil Nil N/A Intermittent exotropia bilaterally Alive with SD 5.81
16 Nil No Nil Nil Nil N/A Migraine Alive with SD 4.94
17 ETV Yes Nil Nil Nil N/A Memory problem, NF-1 related Alive with SD 4.51
18 ETV Yes Nil Nil Nil N/A HA? Migraine Alive with SD 3.64
19 ETV Yes Nil Nil Nil N/A Abnormal EEG Alive with SD 1.49
20 ETV Yes Nil Nil Nil N/A Nil Alive with SD 1.49
21 ETV Yes Nil Nil Nil N/A Nil Alive with SD 1.24
22 ETV No Bx upfront Nil Nil N/A Nil Alive with SD 0.51
  1. ADHD attention-deficit hyperactivity disorder, Bx biopsy, CP cerebral palsy, CSF cerebrospinal fluid, CN cranial nerve, ETV endoscopic third ventriculostomy, GHD growth hormone deficiency, GTR gross total resection, HA headache, L left, N nausea, NF-1 neurofibromatosis type 1, OA optic atrophy, PD progressive disease, R right, RT radiotherapy, SD stable disease, V vomiting, VF visual field, VPS ventriculo-peritoneal shunt, y year(s)
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