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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis

Fig. 5

Genome-wide DNA methylation profiling support tectal glioma as a molecularly distinct entity. a t-SNE plot and b dendrogram of unsupervised cluster analysis comparing DNA methylation profile of tectal glioma with those of 10 other brain tumor entities including PAs of nearby sites (cerebellum, CBPA, and hypothalamus, HTPA), rosette-forming glioneuronal tumor (RGNT), dysembryoplastic neuroepithelial tumor (DNET), ganglioglioma (GG), subependymal giant cell astrocytoma (SEGA), MYB-altered LGG, histone H3 K27M-mutant diffuse midline glioma (DMG) and IDH-mutant diffuse astrocytoma (AIDH) / oligodendroglioma (OIDH), and normal tissue from hypothalamus (Hyp), pons, cerebellum (CB) and white matter (WM) demonstrate that tectal glioma forms a distinct cluster

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