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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis

Fig. 4

Histologic features of tectal glioma. a Most tectal gliomas demonstrate typical morphologic features of pilocytic astrocytoma, including alternating loose and more compact architecture, bland cytology, Rosenthal fibers, and sclerotic vessels, as well as glomeruloid microvascular proliferation. b, c The tumor cells are diffusely and strongly positive for GFAP and Olig2. d Occasional entrapped axons are highlighted by neurofilament (NFP) staining. e Ki67 labeling is minimal. f BRAF V600E mutant protein is detected by immunohistochemical staining in a few cases. g Occasionally, tectal glioma may have a more diffuse growth pattern, similar to that of a diffuse astrocytoma, with numerous entrapped axons (highlighted by NFP staining, h)

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