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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation

Fig. 1

PKCγ mutations. a Domain structure of PKCγ. The localization of all reported SCA14 mutations is indicated. The two mutations investigated in this study (H36R, H101Q) are highlighted in bold. PKCγ is phosphorylated (P) at three conserved sites: at T514 in the catalytic domain and at T655 and T674 in the C-tail. PS: pseudosubstrate. b Sequence alignment of the two cysteine-rich subdomains C1A and C1B. The histidine residues at positions 36 and 101 (highlighted in bold) are located at equivalent positions within the two subdomains

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