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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein

Fig. 6

Comparison of the secondary structure of PrPSc materials by infrared microspectroscopy. a Second derivative IR microspectra obtained from PrPSc material purified in the form of PrP27–30 from three individual SSLOW-infected hamsters (these spectral data originate from the study [31]). b Second derivative IR microspectra obtained from PrPSc material purified in the form of PrP27–30 from three individual hamsters (i, ii, and iii) from the second passage of SSLOWPE + PolyA. Technical replicate spectra were acquired for each hamster at three different positions in PrPSc sample spots dried on CaF2 windows. c Second derivative IR microspectra obtained from PrPSc material purified in the form of PrP27–30 from one 263K scrapie hamster brain. Technical replicate spectra were acquired at three different positions in PrPSc sample spots dried on a CaF2 window. Similar spectra of highly purified PrPSc from 263K scrapie hamster brain were previously published elsewhere [16, 57]

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