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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein

Fig. 5

Comparison of neuropathological features of SSLOWPE + PolyA and SSLOW. a, b Both SSLOWPE + PolyA and SSLOW shows similar patterns of PrPSc accumulation in cortex including deposition in subpial area (black arrowhead), strong deposition in deeper layers of cortex (white arrowhead), and plaques in subependymal areas (arrow). c Cortex of 263K-infected animals displays different pattern of PrPSc deposition (dg). Subependymal plaques (d, e) and subpial deposition of PrPSc (f, g) in SSLOWPE + PolyA (d, f) and SSLOW (f, g) animals. Scale bars = 300 μm (a-c) or 200 μm (d-g)

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