Fig. 3
From: Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein
Histopathological analysis of animals from the first passage of rPrPresPE + PolyA. PrPSc was found in form of diffused synaptic deposition and small aggregates in subpial areas (a), deep layers of cortex (b), thalamus (c), cerebellum (e), hippocampus (f), and subventricular regions (g). Stratum-lacunosum (s-l) of hippocampus has characteristically intense deposition of PrPSc (f, h) with a pattern reminiscent of SSLOW [30, 43, 45]. Hematoxylin and eosine staining revealed moderate vacuolation in several brain areas including thalamus (d). Scale bars = 200 μm (a-d, g, h) or 300 μm (e, f)