Table 1 Characteristics of the patient population (N = 583)
|
Anaplastic astrocytoma IDH-wildtype N (% of Total) |
Glioblastoma IDH-wildtype N (% of Total) |
Anaplastic astrocytoma IDH-mutant N (% of Total) |
Glioblastoma IDH-mutant N (% of Total) |
Anaplastic oligodendroglioma IDH-mutant and 1p/19q-codeleted N (% of Total) | |
|---|---|---|---|---|---|
| Total | 6 | 138 | 80 | 124 | 227 |
| Median age, years (range) | 52 (26–60) | 59 (16–83) | 37 (18–75) | 38 (19–78) | 48 (19–80) |
| Gender | |||||
| Female | 2 (33) | 60 (44) | 35 (44) | 53 (43) | 101 (44) |
| Male | 4 (67) | 78 (56) | 45 (56) | 71 (57) | 126 (56) |
| Median preoperative KPS% (range) | 90 (90–100) | 80 (40–100) | 90 (60–100) | 90 (50–100) | 90 (50–100) |
| Resection | |||||
| Gross total resection | 1 (17) | 57 (41) | 18 (23) | 34 (27) | 81 (36) |
| Subtotal resection | 2 (33) | 37 (27) | 38 (48) | 43 (35) | 58 (26) |
| Biopsy | 2 (33) | 25 (18) | 9 (11) | 35 (28) | 66 (29) |
| Unknown | 1 (17) | 19 (14) | 15 (19) | 12 (10) | 22 (10) |
| Adjuvant treatment | |||||
| None | 0 | 3 (2) | 3 (4) | 1 (1) | 9 (4) |
| RT alone | 1 (17) | 3 (2) | 5 (6) | 3 (2) | 42 (19) |
| RT + PCV | 0 | 2 (1) | 15 (19) | 16 (13) | 72 (32) |
| PCV alone | 0 | 2 (1) | 0 | 0 | 6 (3) |
| RT + TMZ | 5 (83) | 104 (75) | 38 (48) | 73 (59) | 70 (31) |
| TMZ alone | 0 | 5 (4) | 3 (4) | 4 (3) | 5 (2) |
| No data | 0 | 19 (14) | 16 (20) | 27 | 23 (10) |
| IRS Score | |||||
| IRS = 0 | 5 (83) | 86 (62) | 31 (39) | 47 (38) | 69 (30) |
| 1 ≥ IRS < 4 | 0 | 33 (24) | 27 (34) | 46 (37) | 51 (22) |
| IRS ≥ 4 | 1 (17) | 19 (14) | 22 (27) | 31 (25) | 107 (47) |