Skip to main content

Table 5 Comparison of the inflammatory protein loads (%) in control and Alzheimer’s cases

From: Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

 

Ctrl-

Ctrl+

AD-

AD+

Mean difference (95% CI)

P value

Grey Matter

 Iba1

1.63 ± 0.88

1.81 ± 1.14

1.31 ± 0.75

1.35 ± 1.14

 

ns

 CD68a

0.21 ± 0.08

0.25 ± 0.05

0.29 ± 0.14

0.28 ± 0.14

0.06 (0.007, 0.103)

0.026

 HLA-DR

0.03 ± 0.05

0.04 ± 0.07

0.12 ± 0.16

0.11 ± 0.27

 

ns

 CD64a

2.01 ± 0.85

2.26 ± 1.35

3.16 ± 1.57

2.97 ± 1.55

0.93 (0.36, 1.45)

0.002

 CD32a

0.43 ± 0.33

0.46 ± 0.61

0.45 ± 0.58

0.36 ± 0.46

 

ns

 CD32ba

0.08 ± 0.10

0.10 ± 0.10

0.29 ± 0.52

0.42 ± 1.00

0.27 (−0.001, 0.54)

ns

 CD16b

0.35 ± 0.39

0.86 ± 1.25

0.98 ± 0.90

0.67 ± 0.93

Ctrl+: 0.51 (− 0.07, 1.08)

0.084

AD-: 0.62 (0.13, 1.12)

0.014

AD+: 0.31 (−0.15, 0.78)

0.179

 CHI3L1a

0.24 ± 0.22

0.37 ± 0.36

0.57 ± 0.62

0.73 ± 0.96

0.34 (0.07, 0.62)

0.016

 IL4Ra

0.09 ± 0.08

0.07 ± 0.06

0.23 ± 0.33

0.20 ± 0.24

0.14 (0.04, 0.23)

0.005

 CCR2a

0.12 ± 0.14

0.09 ± 0.08

0.74 ± 1.49

0.38 ± 0.50

0.46 (0.11, 0.80)

0.010

White Matter

 Iba1

1.46 ± 1.03

2.13 ± 1.52

1.27 ± 1.02

1.43 ± 1.13

 

ns

 CD68b

0.11 ± 0.10

0.23 ± 0.17

0.36 ± 0.22

0.28 ± 0.24

Ctrl+: 0.12 (− 0.01, 0.25)

0.076

AD-: 0.25 (0.14, 037)

< 0.001

AD+: 0.17 (0.06, 0.27)

0.003

 HLA-DR

0.05 ± 0.08

0.03 ± 0.06

0.15 ± 0.24

0.09 ± 0.23

 

ns

 CD64b

0.70 ± 0.42

1.95 ± 1.46

1.36 ± 0.89

1.65 ± 1.02

Ctrl+: 1.25 (0.63, 1.87)

< 0.001

AD-: 0.66 (0.12, 1.2)

0.017

AD+: 0.95 (0.45, 1.45)

< 0.001

 CD32aa

0.58 ± 0.67

0.48 ± 0.52

0.34 ± 0.46

0.27 ± 0.37

−0.23 (− 0.43, 0.02)

0.030

 CD16

0.10 ± 0.14

0.31 ± 0.51

0.28 ± 0.30

0.23 ± 0.49

 

ns

 CHI3L1

0.23 ± 0.26

0.50 ± 0.57

0.69 ± 0.73

0.62 ± 1.12

 

ns

 CCR2

0.06 ± 0.11

0.12 ± 0.13

0.30 ± 0.55

0.18 ± 0.46

 

ns

  1. Values are mean ± SD; significant p value in italic
  2. aAlzheimer’s effect
  3. bOne-way ANOVA test performed following significant Alzheimer’s disease*infection interaction on the 2-way ANOVA analysis
  4. ns, non-significant following the 2-way ANOVA analysis
  5. Ctrl neurologically/cognitively normal controls, AD Alzheimer’s disease cases, − died without systemic infection, + died with systemic infection, SD standard deviation, CI confidence interval
Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us