Skip to main content

Table 4 Comparison of inflammatory proteins in Alzheimer’s cases detected by V-PLEX Meso Scale Discovery Multiplex Assays

From: Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

  AD- AD+ P value Fold change
Pro-inflammatory Panel 1 (pg/ml)
 IFN γ 0.18 (0.00, 0.87) 0.00 (0.00, 0.63) 0.266  
 IL1 β 0.00 (0.00, 0.65) 0.36 (0.00, 0.95) 0.097  
 IL2 0.32 (0.16, 0.56) 0.24 (0.00, 0.51) 0.393  
 IL4 0.33 (0.27, 045) 0.33 (0.25, 0.40) 0.834  
 IL6 2.74 (1.48, 4.35) 4.09 (2.14, 11.45) 0.047 1.5
 IL8 15.35 (9.77, 31.44) 17.44 (11.46, 41.99) 0.242  
 IL10 0.05 (0.00, 0.21) 0.08 (0.00, 0.20) 0.747  
 IL12p70 1.60 (1.25, 2.21) 1.81 (1.17, 2.06) 0.736  
 IL13 10.95 (9.50, 16.72) 11.70 (9.51, 15.29) 0.869  
 TNFα 0.49 (0.37, 0.69) 0.57 (0.23, 0.72) 0.874  
Cytokines Panel 1 (pg/ml)
 IL1α 0.67 (0.00, 2.42) 0.46 (0.00, 2.64) 0.781  
 IL5 0.08 (0.04, 0.18) 0.04 (0.01, 0.08) 0.007 −2.0
 IL7 1.32 (0.81, 1.88) 0.54 (0.26, 1.09) 0.002 −2.6
 IL12/IL23p40 0.70 (0.45, 1.14) 0.31 (0.13, 0.76) 0.001 − 2.3
 IL15 6.32 (4.95, 8.24) 3.88 (2.42, 6.95) 0.008 −1.6
 IL16 614.82 (404–13, 1031.83) 261.12 (151.69, 468.25) < 0.001 −2.4
 IL17A 4.57 (3.53, 5.04) 1.90 (1.05, 4.03) < 0.001 −2.4
 GM-CSF 0.70 (0.03, 0.14) 0.04 (0.00, 0.14) 0.463  
 TNFβ 0.00 (0.00, 0.05) 0.00 (0.00, 0.02) 0.561  
 VEGF 10.94 (4.78, 21.70) 7.75 (2.70, 17.52) 0.242  
  1. Values are median with IQR; p value by Mann-Whitney test; significant p values in italic
  2. Fold change, AD+ vs. AD-
  3. AD Alzheimer’s disease cases, − died without systemic infection, + died with systemic infection, IQR interquartile range